Flight Dispatchers often experience fatigue and stress on the job due to work-related factors. Performance impairment resulting from fatigue and job-stress is an important concern for aviation safety. The goal of this research was to investigate fatigue and job-stress factors for flight dispatchers. The research involved an extensive literature review of job characteristic, fatigue and job-stress, human factors in the general and specific (airline operation) environment and surveyed fatigue and job-stress level of flagship carrier's flight dispatcher compared to the other occupation groups. Specially flight dispatchers reported that night work created high level of fatigue and job requirement induced high level of stress. In addition, implications for fatigue and stress management were discussed.