Epidemiological Aspects of Hepatitis E Virus Infections between South Korea and Japan
1Faculty of Health and Nutrition, Otemae University, Osaka, Japan, 2College of Veterinary Medicine, Konkuk University, 3Aeromedical Center of Korean Air, Seoul, KoreaCorrespondence to:
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Korean J Aerosp Environ Med 2022; 32(1): 27-31
Published April 30, 2022
Copyright © Aerospace Medical Association of Korea.
Methods: The raw data on confirmed of HEV infection cases were obtained from the National Notified Disease Surveillance System of Korea Diseases Control and Prevention Agency, the Ministry of Health and Welfare in Korea, and the National Epidemiological surveillance of Infectious Diseases surveillance system, administered by the National Institute of Infectious Diseases in Japan. Statistically significant differences between the epidemiological aspects and risk factors were determined using the Pearson’s chi-squared test or paired t-test. All data analyses were performed in Microsoft Excel 2010 (Microsoft, Redmond, WA, USA).
Results: There were 191 cases of HEV infected cases with a prevalence rate (PR) of 0.37 per 100,000 populations of Korea in 2020. During the same year in Japan, there were 454 cases with a PR of 0.36. When compared, there is statistically none significantly differences. Moreover, both PR per 100,000 populations of HEV infections in habitat of two countries were compared, in the provinces (0.39) of Korea were much higher than that in capital city of Seoul (0.27; P<0.01), but that in Japan were capital city of Tokyo (0.84) was higher than that of the provinces (0.30; P<0.01). Male to female morbidity ratio was 1.65 and 3.78 in Korea and Japan, respectively. The distribution by the age adjusted groups were similar in Korea and Japan that the total cases occurred in the over 40-years-old age bracket, clearly showing a higher incidence in the elderly.
Conclusion: We believed that the HEV are a zoonotic virus, and human occurs mainly through the fecal contamination of water and consumption of contaminated meat from infected animals. In addition, HEV infection can be a problem for pilots and air traffic controllers as well, requiring further investigation and research.
- World Health Organization. Hepatitis E [Internet]. Geneva: World Health Organization; 2021 [updated 2021 Jul 27; cited 2022 Feb 11]. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e.
- Aslan AT, Balaban HY. Hepatitis E virus: epidemiology, diagnosis, clinical manifestations, and treatment. World J Gastroenterol 2020;26:5543-5560. https://doi.org/10.3748/wjg.v26.i37.5543
- Park WJ, Park BJ, Ahn HS, Lee JB, Park SY, Song CS, et al. Hepatitis E virus as an emerging zoonotic pathogen. J Vet Sci 2016;17:1-11. https://doi.org/10.4142/jvs.2016.17.1.1
- Yoon Y, Jeong HS, Yun H, Lee H, Hwang YS, Park B, et al. Hepatitis E virus (HEV) seroprevalence in the general population of the Republic of Korea in 2007-2009: a nationwide cross-sectional study. BMC Infect Dis 2014;14:517. https://doi.org/10.1186/1471-2334-14-517
- Treagus S, Wright C, Baker-Austin C, Longdon B, Lowther J. The foodborne transmission of hepatitis E virus to humans. Food Environ Virol 2021;13:127-145. https://doi.org/10.1007/s12560-021-09461-5
- Owada Y, Oshiro Y, Inagaki Y, Harada H, Fujiyama N, Kawagishi N, et al. A nationwide survey of hepatitis E virus infection and chronic hepatitis in heart and kidney transplant recipients in Japan. Transplantation 2020;104:437-444. https://doi.org/10.1097/TP.0000000000002801
- Nan Y, Wu C, Zhao Q, Zhou EM. Zoonotic hepatitis E virus: an ignored risk for public health. Front Microbiol 2017;8:2396. https://doi.org/10.3389/fmicb.2017.02396
- Centers for Disease Control and Prevention. Hepatitis E questions and answers for health professionals [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; 2020 [updated 2020 Jun 22; cited 2022 Feb 12]. Available from: https://www.cdc.gov/hepatitis/hev/hevfaq.htm.
- Kanayama A, Arima Y, Yamagishi T, Kinoshita H, Sunagawa T, Yahata Y, et al. Epidemiology of domestically acquired hepatitis E virus infection in Japan: assessment of the nationally reported surveillance data, 2007-2013. J Med Microbiol 2015;64:752-758. https://doi.org/10.1099/jmm.0.000084.
- Inagaki Y, Oshiro Y, Tanaka T, Yoshizumi T, Okajima H, Ishiyama K, et al. A nationwide survey of hepatitis E virus infection and chronic hepatitis E in liver transplant recipients in Japan. EBioMedicine 2015;2:1607-1612. https://doi.org/10.1016/j.ebiom.2015.09.030
- Tohme RA, Drobeniuc J, Sanchez R, Heseltine G, Alsip B, Kamili S, et al. Acute hepatitis associated with autochthonous hepatitis E virus infection--San Antonio, Texas, 2009. Clin Infect Dis 2011;53:793-796. https://doi.org/10.1093/cid/cir453
- Kim BS, Lim HS, Lee K, Min YS, Yoon YS, Jeong HS. A survey on the status of hepatitis E virus infection among slaughterhouse workers in South Korea. J Prev Med Public Health 2015;48:53-61. https://doi.org/10.3961/jpmph.14.048
- Okamoto H, Takahashi M, Nishizawa T. Features of hepatitis E virus infection in Japan. Intern Med 2003;42:1065-1071. https://doi.org/10.2169/internalmedicine.42.1065
- Infectious Disease Portal. Hepatitis E infections [Internet]. Cheongju: Korea Disease Control and Prevention Agency; 2020 [updated 2021 Jan 6; cited 2022 Feb 12]. Available from: https://www.kdca.go.kr/npt/biz/npp/portal/nppSumryMain.do?icdCd=NB0021&icdgrpCd=02.
- National Institute of Infectious Diseases, Japan. Hepatitis E infections [Internet]. Tokyo: National Institute of Infectious Diseases, Japan; 2020 [updated 2020 Feb 4; cited 2022 Feb 12]. Available from: https://www.niid.go.jp/niid/ja/diseases/a/hepatitis/hepatitis-e.html.